Colostrinin Decreases Hypersensitivity and Allergic Responses to Common Allergens.
International Archives of Allergy and Immunology, 146, 298-306.
Boldogh, I., Aguilera-Aguirre, L., Bacsi, A., Choudhury, B. K., Saavedra-Molina, A. & Kruzel, M.
Departments of aMicrobiology and Immunology and bInternal Medicine, University of Texas Medical Branch, Galveston, Tex., and cPharmaReview Corporation, Houston, Tex., USA; dInstitute of Immunology, University of Debrecen, Debrecen, Hungary; eInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México.
Background: Colostrinin™ (CLN), isolated from mothers’ pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma( is a rare, usually noncancerous (benign) tumor that develops in an adrenal gland) cells, extends the lifespan of diploid fibroblast (a cell in connective tissue which produces collagen and other fibres)cells, inhibits β-amyloid-induced apoptosis(the death of cells which occurs as a normal and controlled part of an organism's growth or development.) and improves cognitive functions when administered to Alzheimer’s (progressive mental deterioration that can occur in middle or old age, due to generalized degeneration of the brain. It is the commonest cause of premature senility.)disease patients. Objective: The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens. Methods:We used a well-characterized mouse model of allergic airway inflammation. Changes in IgE/IgG1 and mucin(a glycoprotein constituent of mucus.) levels, airway eosinophilia (an increase in the number of eosinophils in the blood, occurring in response to some allergens, drugs, and parasites, and in some types of leukaemia) and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, (A plethysmograph is an instrument for measuring changes in volume within an organ or whole body) respectively. Results: CLN did not increase IgE/IgG1 levels or induce cutaneous (relating to or affecting the skin) hypersensitivity reaction, airway inflammation and mucin (Mucins are major glycoprotein components of the mucous that coats the surfaces of cells lining the respiratory, digestive, and urogenital tracts, and in some amphibia, the skin) production. Importantly, CLN significantly (p < 0.001) decreased IgE/IgG1 production, airway eosinophilia(an increase in the number of eosinophils in the blood, occurring in response to some allergens, drugs, and parasites, and in some types of leukaemia), mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites. Conclusion: CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.
CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.Colostrinin (PRP) significantly reduced IgE and IgG1 production, airway eosinophilia, mucin production, and hypersensitivity induced by allergen extracts from ragweed pollen grains and house dust mites.
فرع الاردن : مقابل شركة مياهنا, عمارة الجليل, شارع الجليل, جبل الحسين, عمان, الأردن
رقم الهاتف : 0096264600444 - 00962778455550 - 00962781409934 - 00962790633919
فرع الامارات :
شارع الشرق, الشارقة, الامارات العربية المتحدة
رقم الهاتف : 00971600560003