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The effect of alfalfa-corn diets on cholesterol metabolism and gallstones in prairie dogs.

The effect of alfalfa-corn diets on cholesterol metabolism and gallstones in prairie dogs.



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title The effect of alfalfa-corn diets on cholesterol metabolism and gallstones in prairie dogs.  
  2 Abstract Source Lipids, 25, 143-148.  
  3 Abstract Author(s) Cohen, B. I., Mosbach, E. H., Matoba, N., Suh, S. O. & Mcsherry, C. K.   
  4 Article Affiliation Department of SurgeryBeth Israel Medical CenterNew York.  
  5 Abstract Cholesterol gallstones (The most common type of gallstone, called a cholesterol gallstone, often appears yellow in color. These gallstones are composed mainly of undissolved cholesterol, but may contain other components. Pigment gallstones. These dark brown or black stones form when your bile contains too much bilirubin)were present in prairie dogs fed alfalfa (Alfalfa(Medicago sativa)also called Lucerne, is naturally high in many essential vitamins and minerals, including A, D, E, K, and even the full family of B vitamins; biotin, calcium, folic acid, iron, magnesium, potassium and many others, as well as being very high in protein, especially when dried. It is "The king of all foods"!)plus corn with and without exogenous (having an external cause or origin)cholesterol (0.4%). The diets fed to the animals for eight weeks contained alfalfa plus corn in fixed proportions of 50∶50, 85∶15 and 15∶85 (w/w). At sacrifice, all animals were healthy but had not gained weight; no deaths occurred during the experiment. Cholesterol gallstones were present in all groups. In the absence of exogenous cholesterol, the highest stone incidence was found in the animals which received the lowest fiber (highest corn) diets (alfalfa plus corn, 50∶50, 67%; alfalfa plus corn, 15∶85, 83%). Cholesterol gallstone incidence was 100% when exogenous cholesterol was added to the alfalfa plus corn diets (50∶50 and 15∶85). No pigment gallstones were detected in any animal. Liver and plasma cholesterol concentrations were highest in the animals receiving alfalfa plus corn (15∶85) plus 0.4% cholesterol (4.29 mg/g, and 356 mg/dl, respectively). These values were lowest in animals receiving 85% alfalfa plus 15% corn without cholesterol (2.19 mg/g and 88 mg/dl, respectively). Lithogenic (Promoting the formation of calculi)indices were below 1.00 in all groups. Biliary bile acids were mainly amidates of cholic acid and chenodeoxycholic acid, with the former predominating. Thus, gallstones can be formed in prairie dogs in the absence of exogenous cholesterol; gallstone incidence is reduced by dietary fiber.(dietary material containing substances such as cellulose, lignin, and pectin, that are resistant to the action of digestive enzymes)  
  6 Summary Thus, gallstones can be formed in prairie dogs in the absence of exogenous cholesterol; gallstone incidence is reduced by dietary fiber.  
  7 Article Published Date March-1990  
  8
Study Type invivo  
  9
Substances alfalfa  
  10
Diseases cholesterol gallstones  
  11 Pharmacological Actions removing gallstones  
  12
Link https://goo.gl/mzD1U6  
       

 


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