أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

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Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).

Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).  
  2 Abstract Source British Journal of Nutrition, 78, 325-334.  
  3 Abstract Author(s) Gray, A. M. & Flatt, P. R.  
  4 Article Affiliation School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA.  
  5 Abstract Medicago sativa (lucerne) is used as a traditional plant treatment of diabetes(Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy). In the present study, administration of lucerne ( Lucerne or alfalfa (Medicago sativa) is a deep-rooted, temperate, perennial pasture legume which is well adapted to mixed farming systems in southern Western Australia)in the diet (62·5 g/kg) and drinking water (2·5 g/l) reduced the hyperglycaemia (medical term for a high blood sugar (glucose) level)of streptozotocin-diabetic mice (Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes). An aqueous extract of lucerne (1 mg/ml) stimulated 2-deoxy-glucose transport (1·8-fold), glucose oxidation (1·7-fold) and incorporation of glucose into glycogen (l·6-fold) in mouse abdominal muscle. In acute 20 min tests, 0·25–1 mg/ml aqueous extract of lucerne evoked a stepwise 2·5–6·3-fold stimulation of insulin secretion from the BRIN-BD11 pancreatic B-cell line. This effect was abolished by 0·5 mM-diazoxide, and prior exposure to extract did not affect subsequent stimulation of insulin (a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body.)secretion by 10 mM-L-alanine, thereby negating a detrimental effect on cell viability. The effect of extract was potentiated by 16·7 mM-glucose and by 1 mM-3-isobutyl-1-methylxanthine. L-Alanine (10 mM) and a depolarizing ( the negative internal charge of the cell temporarily becomes more positive (less negative))concentration of KCI (25 mM) did not augment the insulin-releasing activity of lucerne. Activity of the extract was found to be heat stable and largely acetone insoluble, and was enhanced by exposure to acid and alkali (0·1 M-HCI and NaOH) but decreased 25% with dialysis to remove components with molecular mass <2000 Da. Sequential extraction with solvents revealed insulin-releasing activity in both methanol and water fractions indicating a cumulative effect of more than one extract constituent. The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativu.  
  6 Summary  Sequential extraction with solvents revealed insulin-releasing activity in both methanol and water fractions indicating a cumulative effect of more than one extract constituent. The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativu.  
  7 Article Published Date Aug-1997  
  8
Study Type Invitro  
  9
Substances alfalfa  
  10
Diseases Diabetes  
  11 Pharmacological Actions antidiabetic  
  12
Link https://goo.gl/DxbMsc  
       

 


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