أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

85309810

Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult.

Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult.



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult.  
  2 Abstract Source Evidence-Based Complementary and Alternative Medicine, 2011.  
  3 Abstract Author(s) Bora, K. S. & Sharma, A.  
  4 Article Affiliation L.R. Institute of Pharmacy, Solan 173 223, India.  
  5 Abstract Antioxidants (An antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that can produce free radicals, leading to chain reactions that may damage cells)have been the focus of studies for developing neuroprotective agents (substances that are capable of preserving brain function and structure. When the brain is exposed to high levels of oxidative stress, mitochondrial dysfunction, inflammation, various forms of neurotoxicity (e.g. excitotoxicity), and protein deficiencies – neurodegeneration can occur)to be used in the therapy for stroke,(A stroke occurs when the blood supply to your brain is interrupted or reduced. This deprives your brain of oxygen and nutrients, which can cause your brain cells to die. A stroke may be caused by a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke)) which is an acute and progressive neurodegenerative disorder (an umbrella term for a range of conditions which primarily affect the neurons in the human brain. Neurons are the building blocks of the nervous system which includes the brain and spinal cord.)Medicago sativa (MS) has a long tradition of use as ayurvedic (the traditional Hindu system of medicine (incorporated in Atharva Veda, the last of the four Vedas), which is based on the idea of balance in bodily systems and uses diet, herbal treatment, and yogic breathing.)and homoeopathic (a system of complementary medicine in which ailments are treated by minute doses of natural substances that in larger amounts would produce symptoms of the ailment.)medicine in central nervous system disorders. The plant has been reported to have antioxidant, anti-inflammatory and antidiabetic effects. Therefore, the present study was designed to investigate the neuroprotective effect of methanol extract of MS on ischemia (an inadequate blood supply to an organ or part of the body, especially the heart muscles.)and reperfusion-induced cerebral injury (is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia))in mice. Bilateral carotid artery occlusion (BCAO)(Bilateral carotid occlusive disease is a rare but hemodynamically critical state as patients often rely on the posterior communicating artery or retrograde filling from the ophthalmic artery to maintain adequate perfusion) for 15 min followed by 24-h reperfusion, resulted in significant elevation in infarct size, xanthine oxidase (XO) activity, superoxide anion (O•−2) production and thiobarbituric acid-reactive substance (TBARS) levels,(TBARS is Thiobarbituric acid reactive substances. This is a biproduct of lipid peroxidation. Lipid peroxidation is measured in the form of TBA- RS) and significant depletion in endogenous antioxidant [reduced glutathione (GSH), (Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals.)superoxide dismutase (SOD) (Superoxide Dismutase (SOD) is an enzyme that repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body.)and total tissue sulfhydryl (T-SH) groups] systems in mice brain. Further, BCAO led to impairment in short-term memory and motor coordination. Pre-treatment with MS (100 or 200 mg kg−1, p.o.) markedly reduced cerebral infarct size, XO, O•−2 and TBARS levels, significantly restored GSH, SOD and T-SH levels and attenuated impairment in short-term memory and motor coordination. In addition, MS directly scavenged free radicals generated against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O•−2 generated in phenazine methosulphate-nicotinamide adenine dinucleotide systems, and also inhibited XD/XO conversion and resultant O•−2 production. The data from this study suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.  
  6 Summary MS directly scavenged free radicals generated against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O•−2 generated in phenazine methosulphate-nicotinamide adenine dinucleotide systems, and also inhibited XD/XO conversion and resultant O•−2 production. The data from this study suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.  
  7 Article Published Date 2011  
  8
Study Type invivo  
  9
Substances alfalfa  
  10
Diseases oxidation  
  11 Pharmacological Actions Antioxidants   
  12
Link https://goo.gl/r6poVp  
       

 


videos balancecure

شاركها مع اصدقائك



اشترك بالقائمة البريدية


التعليقات

لا يوجد تعليقات

أضف تعليقًا

Made with by Tashfier

loading gif
feedback